Glucagon-like peptide-1 (GLP-1) receptor agonists (Formulary)

MHRA advice: GLP-1 receptor agonists: reports of diabetic ketoacidosis when concomitant insulin was rapidly reduced or discontinued (June 2019) (www.gov.uk).

Refer to protocol for use of GLP-1 analogues.

LIRAGLUTIDE - (First line)

Important: Therapy notes

First line once daily option.

MHRA advice: Ozempic (semaglutide) and Saxenda (liraglutide): vigilance required due to potentially harmful falsified products (November 2023) (www.gov.uk).


Important: Formulation and dosage details

Formulation:

Injection, pre-filled pen 18mg/3mL

SEMAGLUTIDE - (First line)

Important: Therapy notes

First line once weekly option.

MHRA advice: Ozempic (semaglutide) and Saxenda (liraglutide): vigilance required due to potentially harmful falsified products (November 2023) (www.gov.uk).


Important: Formulation and dosage details

Formulation:

Solution for injection, pre-filled pen (Ozempic) 0·25mg, 0·5mg and 1mg

Important: Formulation and dosage details

Formulation:

Tablets (Rybelsus) 3mg, 7mg and 14mg

Dosage:

Oral, once daily alternative to subcutaneous semaglutide - when subcutaneous route not suitable.

DULAGLUTIDE - (Second line)

Important: Therapy notes

Second line once weekly option.

Important: Formulation and dosage details

Formulation:

Injection, pre-filled pen 750 micrograms/0·5mL, 1·5mg/0·5mL 

Editorial Information

Last reviewed: 11/02/2021

Approved By: TAM Subgroup

Document Id: F175