Important: Formulation and dosage details

Formulation:

Tablets 5mg, 7·5mg

Dosage:

Angina: (for people in sinus rhythm) initially 5mg twice daily, increased if necessary after 3 to 4 weeks to 7·5mg twice daily (if not tolerated reduce dose to 2·5 to 5mg twice daily); older people initially 2·5mg twice daily.
Chronic heart failure NYHA II to IV with systolic dysfunction, in patients in sinus rhythm whose resting heart rate remains at 75 or more beats per minute despite optimal standard therapy: (specialist use only) initially 5mg twice daily, increased if necessary after 2 weeks to 7·5mg twice daily (if not tolerated reduce dose to 2·5mg twice daily). Ventricular rate at rest should not be allowed to fall below 50 beats per minute.

Important: Formulation and dosage details

Formulation:

Tablets 10mg, 20mg

Dosage:

Initially 10mg twice daily (if susceptible to headache, 5mg twice daily), usual dose 10 to 20mg twice daily; up to 30mg twice daily may be used.