Vitamin K is used in patients with high INRs and/or patients on warfarin who are bleeding.  It takes 12 to 24 hours to act.  It may be given orally using the intravenous preparation or intravenously. The dose is dependent on the INR, the degree of reversal required and whether there is a need for re-anticoagulation in the near future. Vitamin K does not reverse anticoagulation with heparin, dabigatran, apixaban or rivaroxaban.

MENADIOL

Important: Therapy notes

BNF

Important: Formulation and dosage details

Formulation:

Tablets 10mg

Dosage:

Malabsorption syndromes, 10mg daily

PHYTOMENADIONE

Important: Therapy notes

For reversal of warfarin anticoagulation seek advice from Consultant Haematologist.

Prothrombin complex is used in addition to vitamin K in patients who are bleeding and on warfarin or who are anticoagulated and requiring urgent surgery.  It provides temporary but immediate reversal of anticoagulation and can be obtained from the Blood Transfusion Service on the authorisation of a Haematologist. 

BNF

Important: Formulation and dosage details

Formulation:

Injection, in a mixed micelles vehicle (Konakion® MM Paediatric) 2mg/0·2mL

Dosage:

Patients with abnormal coagulation due to vitamin K deficiency or patients on warfarin who are bleeding or who have a high INR. It may take up to 6 to 12 hours to act. The dose and route of administration depends on the indication; if in doubt, discuss with the Consultant Haematologist. 

Notes:

Konakion®MM Paediatric can be administered by intramuscular, intravenous or oral route.  

Important: Formulation and dosage details

Formulation:

(Konakion® MM) 10mg/1mL

Dosage:

Patients with abnormal coagulation due to vitamin K deficiency or patients on warfarin who are bleeding or who have a high INR. It may take up to 6 to 12 hours to act. The dose and route of administration depends on the indication; if in doubt, discuss with the Consultant Haematologist. 

Editorial Information

Document Id: F025