Diagnosis

Based on clinical findings and suppressed TSH, raised thyroid hormones.

Investigations

  • First Line; TSH, free T4, total T3 (or free t3).
  • Second line investigations optional, but preferred; TRAb, USS thyroid, Isotope scan thyroid.

Treatment

First line therapy – Drug treatment.

  • Usually Start with Carbimazole 0.75mg/kg/day.
  • 2 variations in drug treatment; ‘block and replace’ or titration. Continue for 36 months. Stop then reassess.
  • Add Propranolol initially if significant autonomic symptoms/signs.

Second line (treatment failure or relapse after 36 months): – Radioiodine therapy or surgery requiring referral to regional centre.

Eye disease– refer to ophthalmologist.