• Oral antibiotic therapy should be guided by sputum cultures. 

  • Antibiotic choice should not be delayed while culture results are awaited – the choice should be directed by previous positive cultures. 

  • In the absence of previous positive sputum cultures, oral antibiotics to cover common respiratory pathogens are recommended, using local formulary guidance where available. The recommended duration is 14 days. Shorter courses may suffice in those with mild bronchiectasis.62

    • 1st line - amoxicillin 500mg to 1g three times a day62
    • 2nd line - doxycycline 100mg twice a day
  • A first positive culture for Pseudomonas aeruginosa in sputum should trigger a discussion with local bronchiectasis specialists to consider eradication therapy.