Betablocker (Metoprolol modified release titrated to a target dose of 200mg /day) vs placebo

Polypharmacy icon of two pills

Study population:

Patients ith mild to severe heart failure 

NYHA class II - IV) and LVEF </=0.40 despite optimum standard therapy. 

Comments:

Mean age of patients was 64 years.


Optimum standard therapy was defined as any combination of ACE inhibitors, Angiotensin receptor blockers and diuretics. 97% of patients were on an ACE inhibitor or Angiotensin receptor blocker.

 

Outcome Duration NNT Annualised NNT
Prevent one death (all cause) 12 months (mean duration of followup)

28

28

References

Merit H-F Study Group. Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised intervention Trial in Congestive Heart Failure (MERIT-HF). The Lancet. 1999; 353: 2001-2006