Indication

INR Range

(Target INR)

Duration

Venous thrombosis acute

treatment and secondary prevention

2.0-3.0 (target INR: 2.5) See Duration of anticoagulation p18
Non-valvular atrial fibrillation (AF), paroxysmal or permanent AF    
All patients with AF who have CHADS2 or CHA2DS2-VASc of equal to 1 2.0-3.0 (target INR: 2.5) Long term
AF associated with a) clinical thyrotoxicosis b) non-cerebral thromboembolism 2.0-3.0 (target INR: 2.5)

a) Until controlled

b) Long term

Elective cardioversion 2.0-3.0 (target INR: 2.5)

Minimum 3 weeks pre-procedure

Minimum 4 weeks post-procedure

Ongoing requirement as directed by cardiologist

Valvular AF    
Rheumatic mitral valve disease and mitral stenosis 2.0-3.0 (target INR: 2.5) Long term

Mechanical heart valves - Target INR depends on site of valve replacement, position and manufacturer

See recommendations from Cardiothoracic Surgery RIE p31 Lifelong - follow guidance from cardiac unit
Patients requiring anticoagulation and antiplatelet therapy 2.0-3.0 (target INR 2.5) As prescribed by consultant cardiologist/stroke physician/ haematologist
Intracardiac thrombus 2.0-3.0 (target INR 2.5) At least 3 months as prescribed by cardiology