Prophylaxis against for HIV
If the patient presents within 72 hours of sexual assault, then a risk assessment for acquisition of HIV should be performed. Please see UK Guideline for the use of HIV Post-Exposure Prophylaxis 2021
Clinicians should bear in mind that transmission of HIV is likely to be increased by physical genital injury, current STI, presence of bleeding or by multiple assailants or repeated assaults.
Decisions about the need for PEP in the setting of people on PrEP but with less than optimal PrEP adherence depends on length of time since the last dose of PrEP and the site of exposure. Please see Section 10.3 Please see UK Guideline for the use of HIV Post-Exposure Prophylaxis 2021
If the patient is already taking daily Pre-exposure Prophylaxis (PrEP) with tenofovir/emtricitabine, then PEPSE is not required, provided they are taking this correctly, have not missed any doses and continue to take for at least 48 hours following the assault.
Indications for PEP are:
Anal sex: If the only exposure has been though anal sex and for people on daily PrEP, where fewer than 4 pills have been taken in the last 7 days. Or for people on event-based PrEP, PEP is indicated where PrEP has not been taken as recommended.
Vaginal: Where the potential HIV exposure is through vaginal sex and PrEP adherence has been suboptimal, PEP should be considered if more than 48 hours have elapsed since last dosing or if fewer than six tablets have been taken within the previous 7 days.
Frontal or neovaginal sex: Where the potential exposure to HIV is through frontal sex in transmen or through neovaginal sex in trans women, then PEP should be considered if more than 48 hours have elapsed since last dosing or if fewer than six tablets have been taken within the previous 7 days.
Prophylaxis against Hepatitis B
- Hepatitis B vaccine should be offered early, preferably within 24 hours. As post-exposure prophylaxis there is little evidence to support its effectiveness beyond 7 days.
- Delivery of later vaccine beyond the seven days is unlikely to be effective as post exposure prophylaxis however is not likely to cause harm. There may be other indications for offering the vaccine to patients in line with current public health guidance to consider.
- All three schedules are likely to have similar effectiveness as PEP but the accelerated (four doses at 0, 1, 2, and 12 months); or ultra-rapid (four doses at 0, 7– 10 days, 21 days, and 12 months) are preferred because of higher completion rates in addition to rapid development of immunity in those at ongoing risk and where compliance is an issue.
- The adult dose (20mcg /1ml) is licensed for use in those 16 years or over. A licensed lower paediatric dose (10mcg / 0.5ml) of Engerix® is used in children aged 15 years and younger on three-dose regimen. Adolescents aged 11-15 who are not likely to attend for three doses and are at low immediate risk can be offered a two-dose regimen using the adult 20 mcg preparation. This two-dose schedule of a vaccine containing adult strength hepatitis B at zero and six months provides similar protection to three doses of the childhood hepatitis B vaccines.
- As vaccine alone is highly effective, the use of HBIG in addition to vaccine is only recommended in high-risk situations or in a known non-responder to vaccine. Vaccine should be simultaneously offered. Further details on the indications and use of HBIG are available from Public Health England Guidance.
Prophylaxis against Hepatitis A
Post exposure vaccination for Hepatitis A following sexual assault would only be recommend if within two weeks of a contact of a confirmed case or one week after onset of jaundice in the index case.
If rapid protection against hepatitis A is required for adults, for example following exposure or during outbreaks, then a single dose of monovalent vaccine is recommended. In children under 16 years, a single dose of Ambirix® may also be used for rapid protection against hepatitis A. Both vaccines contain the higher amount of hepatitis A antigen and will therefore provide hepatitis A protection more quickly than Twinrix
Opportunistic vaccination against Hepatitis A
The following groups should be opportunistically offered a single dose of adult monovalent hepatitis A vaccine, where available, unless they have documented evidence of two doses of hepatitis A vaccination or of previous hepatitis A illness.
- GBMSM (Gay, Bisexual, Men who have sex with men)
- PWID (People who inject drugs)
- People involved in transactional sex
- Transgender women who have anal sex
- People who are positive for HIV, HCV, HBV.
The Use of Combined Hep A/B Vaccine e.g.Twinrix is off label for use as post exposure prophylaxis. For those eligible and at ongoing risk give separate vaccines where possible. Although off-label, prescribers can use Twinrix if deemed suitable i.e. will refuse two vaccine.
Twinrix is available for use in those being provided both Hepatitis A and B vaccines where the risk of exposure is not as high or ongoing risk where pre exposure vaccination would be routinely recommended.
Human Papilloma Virus (HPV) vaccination
HPV vaccination is not routinely given post sexual assault to those disclosing sexual violence in the acute, post sexual assault setting. We would recommend instead that all survivors are questioned with respect to their HPV vaccination history and all those who are currently eligible for the HPV vaccination as per current UK guidelines are advised and signposted to commence (or complete any incomplete) HPV quadrivalent vaccination courses.
Emergency contraception
If no ongoing contraception in place, offer emergency contraception if indicated. If an IUD is recommended as per Emergency Contraception Guideline ideally wait until after the forensic exam and offer an emergency hormonal method in the interim. Also offer emergency contraception as a precautionary measure if there are concerns about bodily fluids when assault was by penetration by an object or a digit.
A pregnancy test (PT) will be positive at 3 weeks post risk (and sometimes earlier than this)
If a pregnancy test is positive, discuss options which include:
- Continuing with the pregnancy
- Termination of pregnancy
- Paternity testing
- Using products of conception as evidence
If the patient continues with a pregnancy, contact their GP or Antenatal Clinic and share relevant information about the assault, with the patient’s consent. This may include discussion on the option of obtaining a DNA profile from the baby at some time following delivery.
If the patient does not wish to continue the pregnancy, refer to local abortion services. Products of conception may be used as DNA evidence. If this is consented to, abortion services will liaise with Police Scotland on the available options.
STI Testing
Patients should be offered opportunities to test at the end of the incubation period for each STI. Offer testing in all cases where there is a risk of infection, including assault by penetration by an object or a digit if there is any possible risk STI transmission This includes NAAT for CT/GC, bloods for HIV/syphilis/Hep B and Hep C. If the sexual assault was oral/anal penetration, NAATs should also be taken from these sites.
Type of Penetration |
Offer STI testing |
Offer Emergency contraception |
Penile - vaginal |
yes |
yes |
Penile - anal |
yes |
yes |
Penile - oral |
yes |
no |
Digital - vaginal |
* |
* |
Digital - anal |
* |
* |
Oral - vaginal |
Yes |
no |
Oral - anal |
Yes |
no |
*If there is concern about bodily fluids on penetrating digit or object
If a site is sexually naive, please consider sending a chain of evidence form if patient has reported or is considering reporting.
The additional complication of contact tracing suspects is introduced when a patient tests positive for an STI. Undertaking this public health responsibility, whilst retaining patient confidentiality can be complicated and require documentation of discussion with senior colleagues.
|
HIV |
Hepatitis B |
Hepatitis C |
Syphilis |
Additional tests for patients prescribed PPEP |
At presentation |
4th generation HIV serology test |
Hep B core Antibody |
Hep C testing |
EIA |
renal function ALT |
Follow-up |
repeat 45 days after assault; 3 months after commencement of PEP: 4th generation HIV serology test |
repeat 3 months after assault: The incubation period for hepatitis B infection can be up to 160 days. The majority of patients test positive by 3 months. Retest at 6 month if the opportunity arises |
repeat 3 months after assault: Hep C PCR or Ab If Ab used at 3 months then repeat at 6 months if high risk. |
repeat 3 months after assault |
repeat tests not necessary if normal at baseline, and no side effects of PEP |
Prophylaxis against Bacterial Sexual Transmitted Infections
Prophylactic antibiotics for STI risk would not normally be indicated. A pragmatic approach may have to be taken whilst balancing against unnecessary antibiotic prescribing if there is a possibility of not re-attending.
Offering testing after incubation would be the preferred recommendation.
Consider the use of prophylactic antibiotics if patient presents within the 2 week incubation period and is unlikely to re-attend or if patient is symptomatic of a bacterial STI and Emergency Contraception copper coil insertion is being carried out.
At the time of writing, the recommended first line regimens for adults are:
• Chlamydia: Doxycycline 100mg twice daily for 7 days
• Gonorrhoea: Ceftriaxone 1g intramuscular single dose
• Trichomonas: Metronidazole 400mg twice daily for 7 days (or metronidazole 2g oral
single dose in non-pregnant women)