Eligibility, suitability, side effects, and problems

Warning

Eligibility and suitability

Please see UKMEC.

 

Cu-IUD use in specific patient groups

  • The use of intrauterine methods should not be restricted based on age or parity alone.
  • There is evidence that immediate post abortion insertion reduces the number of subsequent unwanted pregnancies and repeated abortions (refer to ‘Timing of insertion’). Women should be informed of the small increase in the risk of expulsion following immediate or early insertion post abortion.
  • For women with cardiac disease the decision to use IUC should involve a cardiologist. The IUC should be fitted in hospital setting if a vasovagal reaction presents a particularly high risk; for example, women with a single ventricle, Eisenmenger physiology, tachycardia or pre existing bradycardia. Fitting should also be in hospital setting in women with known long QT syndrome, since cervical stimulation during insertion can cause a vasovagal reaction with an increased risk of a cardiac event.
  • There is no evidence on the risks of infection in women who are immunocompromised due to drugs that affect the immune system.
  • In women on long term systemic steroids advice should be sought from the women’s physician regarding the need for increased steroid treatment prior to IUC insertion. Women on long term systemic steroids may be at greater risk of cardiovascular collapse during IUC insertion.

 

Assessment of client suitability

Accurate information and empathic counselling is the key to user acceptability.

Clinical history taking and examination allow an assessment of medical eligibility for Cu-IUD use. In this context the history should include relevant:

  • social history
  • medical history
  • sexual history (to assess risk of STIs)
  • family history
  • drug history
  • details of reproductive health
  • details of previous contraceptive use.

With this information clinicians can advise on the appropriate contraceptive options taking account of both medical and social factors.

Women can be encouraged to watch an eight minute online film produced by Lothian Sexual Health which gives information about intrauterine methods of contraception.

Women considering a Cu-IUD should be counselled regarding other contraceptive options including a LNG-IUS.

Counselling should include a discussion about discomfort during or after Cu-IUD insertion and possible benefits, side effects and risks.

STI risk assessment should be performed for all women considering a Cu-IUD. Testing for C. trachomatis and Neisseria gonorrhoeae should be undertaken in women at higher risk of STIs:

  • Aged less than 25 years.
  • Aged 25 years or older and have had a new sexual partner or more than one sexual partner in last year.
  • if their regular partner has other sexual partners, a history of STIs, attending as a previous contact of an STI or has alcohol / substance abuse.

Testing for Chlamydia trachomatis and Neisseria gonorrhoeae should also be done in women who request it.

Women who have epilepsy, are likely to require local anaesthetic, or who have had a previous failed insertion at another clinic should be referred to a clinic with more experienced staff specialising in difficult LNG-IUS insertion.

 

Situations where it may be more appropriate to delay Cu-IUD insertion or give antibiotic prophylaxis

  • Women with symptomatic pelvic infection should be tested, treated, and insertion delayed until symptoms resolve.
  • Asymptomatic gonorrhoea or chlamydia infection should be treated before insertion.
    • If it is not possible to delay insertion, it may be acceptable to treat asymptomatic chlamydia infection at the time of insertion.
    • In asymptomatic women attending for insertion of a Cu-IUD, there is no need to wait for STI results or routinely provide prophylactic antibiotics provided the women can be contacted and treated promptly.
  • There is no indication to routinely test for lower genital tract organisms (such as Group B streptococcus or bacterial vaginosis) in asymptomatic women.
  • If bacterial vaginosis or candida infection is diagnosed or suspected the infection should be treated and the Cu-IUD inserted without delay.
  • Cases of Group A Streptococcus have been reported post IU inserted. Such cases are rare but can include life threatening septicaemia, invasive Group A Streptococcus (such as necrotising fascilities) and Streptococcal toxic shock syndrome.
    • If a women is found to have Group A streptococcus in the vagina she should be treated and the Cu-IUD insertion delayed.
    • In addition, women using an intrauterine method should be advised to seek medical advice if they experience signs or symptoms of infection.
  • NICE guidelines recommend that antibiotic prophylaxis against infective endocarditis is no longer recommended for women for defined interventional procedures. This does not exclude antibiotics on a case by case basis. If there is suspected infection at the site of the genitourinary procedure an antibiotic that covers the organisms that cause infective endocardititis should be considered.

Side effects and risks

Side effects/risks

  • Weight gain has been observed with intrauterine contraceptive use, but there is no significant difference between hormonal and non hormonal methods and evidence to support a causal association is lacking.
  • Pelvic infection:
    • Studies examining a relationship between intrauterine contraception use and PID are subject to limitations, bias, and confounding, and good evidence is lacking.
    • In intrauterine contraception, PID appears most strongly related to the insertion procedure and the background risk of STIs.
    • A review identified a low rate of PID (1.6 per 100 women years). A six fold increase of PID was reported in the 20 days after insertion. After this time the risk was low unless there was exposure to STIs.
  • Displacement or expulsion is the commonest cause of intrauterine contraceptive failure. The risk is around 1 in 20. It is most common in the first year of use, particularly within three months of insertion.
  • Ectopic pregnancy:
    • The overall risk of ectopic pregnancy is very low with IUC use because of its very high efficacy in preventing pregnancy.
    • The risk of ectopic is reduced with intrauterine contraceptive use when compared to using no contraception.
  • The risk of uterine or cervical perforation associated with intrauterine contraception insertion is less than 2 per 1000 insertions. This risk is is approximately six fold higher in breast feeding woman.
  • Bleeding:
    • Some women will have normal bleeding patterns after insertion of a Cu-IUD, however some will experience longer and more frequent bleeding.
    • There is some evidence bleeding patterns tend to improve / settle with time after insertion (more than three months).
    • Discontinuation due to bleeding and pain are similar for different types of framed and unframed CU-IUDs.
    • Gynaecological pathology and infections should be excluded if abnormal bleeding persists beyond the first six months following insertion of intrauterine contraception. However, clinicians should also be aware that abnormal bleeding at any time may indicate the presence of an STI or gynaecological pathology, and when appropriate women should be investigated accordingly.
  • In a large cohort study, pelvic pain or cramping was the most common reported reason for discontinuation of intrauterine contraception at 6 months. 35% of Cu-IUD and 28% of LNG-IUS users reported pelvic pain as the reason for discontinuation: the difference between the two groups was not significantly different.
  • Return to fertility after discontinuation of intrauterine contraception use is generally similar to  after discontinuation of oral contraceptives and barrier methods.
  • No evidence of reduced efficacy with any drugs.

Problems associated with Cu-IUD use

Abnormal bleeding

Gynaecological pathology and infections should be excluded if abnormal bleeding persists beyond the first 6 months following insertion of intrauterine contraception. However, clinicians should also be aware that abnormal bleeding at any time may indicate the presence of an STI or gynaecological pathology, and when appropriate women should be investigated accordingly.

Non-steroidal inflammatory drugs can be considered for the management of problematic bleeding with the use of Cu-IUDs. If that is ineffective antifibrinolytics (tranexamic acid) may be used for heavy or prolonged menstruation.

Women who find heavier bleeding associated with Cu-IUD use unacceptable may consider changing to a LNG-IUS.

Lost threads

See flow chart.

Non fundally placed IUC

The decision to remove and replace a non fundally placed IUC is a matter of individual clinical judgement, following discussion with the woman and consideration of her individual circumstances. There is limited evidence to allow for recommendations.

Pregnancy

Women who conceive with an IUC in situ are at greater risk of adverse pregnancy outcomes such as spontaneous abortion, preterm delivery, septic abortion and chorioamnionitis. The limited evidence available suggests that removal of the IUC early in pregnancy may help improve outcomes. See flow chart to determine whether an attempt should be made to remove the Cu-IUD and ongoing management.

Suspected pelvic infection

Women with symptoms and signs suggestive of pelvic infection - start appropriate antibiotics. There is no need to remove the Cu-IUD unless symptoms fail to resolve within the following 72 hours or unless the woman desires removal.

Arrange follow up to ensure:

  • resolution of symptoms and signs
  • partner notification
  • completion of the course of antibiotics
  • their partner has also been treated when appropriate
  • STI risk assessment
  • counseling regarding safer sex.

Suspected perforation

A recent review of the reported cases of uterine perforation found that only 8% were suspected or detected at the time of insertion.

If suspected at the time of insertion, the procedure should be stopped and vital signs (blood pressure and pulse rate) and level of discomfort monitored until stable.

Management needs to be discussed with a senior clinician.

A history of mild abdominal pain, ‘lost threads’, changes in bleeding, and a history of pain at the time of insertion may suggest perforation when a patient attends for follow up.

When there is any possibility of perforation at the time of insertion or later, an ultrasound scan (USS) and then if indicated a plain abdominal and pelvic X ray to locate the device should be arranged. Women should be advised to use additional contraceptive precautions in the interim.

Presence of actinomyces- like organisms (ALO)

Cu-IUD users with ALO detected on a smear who have no symptoms should be advised there is no reason to remove the Cu-IUD unless signs and symptoms of infection occur. There is no indication for follow-up screening. If symptoms of pelvic pain occur women should be advised to seek medical advice: other causes of infection (in particular STIs) should also be considered and it may be appropriate to remove the Cu-IUD.

References

  1. FSRH Clinical Effectiveness Unit. FSRH Clinical Guideline: Intrauterine Contraception [Internet]. The Faculty of Sexual and Reproductive Healthcare; 2015 Apr [updated 2019 Sep; cited 2022 Oct 14]. Available from: https://www.fsrh.org/standards-and-guidance/documents/ceuguidanceintrauterinecontraception/
  2. National Institute for Health and Care Excellence. Long-acting reversible contraception [Internet]. [London]: NICE; 2005 [updated 2019 Jul; cited 2022 Oct 14]. (Clinical guideline [CG30]). Available from: https://www.nice.org.uk/Guidance/CG30
  3. FSRH Clinical Effectiveness Unit. UK Medical Eligibility Criteria for Contraceptive Use [Internet]. The Faculty of Sexual and Reproductive Healthcare; 2016 Apr [updated 2019 Sep; cited 2022 Oct 07]. Available from: https://www.fsrh.org/documents/ukmec-2016/
  4. FSRH Clinical Effectiveness Unit. FSRH Clinical Guideline: Contraception for Women Aged over 40 Years [Internet]. The Faculty of Sexual and Reproductive Healthcare; 2017 Aug [updated 2019 Sep; cited 2022 Oct 14]. Available from: https://www.fsrh.org/standards-and-guidance/documents/fsrh-guidance-contraception-for-women-aged-over-40-years-2017/
  5. FSRH Clinical Effectiveness Unit. FSRH Clinical Guideline: Contraception After Pregnancy [Internet]. The Faculty of Sexual and Reproductive Healthcare; 2017 Jan [updated 2020 Oct; cited 2022 Oct 14]. Available from: https://www.fsrh.org/standards-and-guidance/documents/contraception-after-pregnancy-guideline-january-2017/
  6. FSRH Clinical Effectiveness Unit. FSRH Clinical Guideline: Contraceptive Choices for Women with Cardiac Disease [Internet]. The Faculty of Sexual and Reproductive Healthcare; 2014 Jun [cited 2022 Oct 14]. Available from: https://www.fsrh.org/standards-and-guidance/documents/ceu-guidance-contraceptive-choices-for-women-with-cardiac/
  7. Lothian Sexual Health. IUDS Pre Insertion Video MP4 [web streaming video]. West of Scotland Sexual Health Managed Clinical Network [cited 2022 Oct 17]. Available from: https://www.wossexualhealthmcn.scot.nhs.uk/wp-content/uploads/2022/03/New_IUDS_VideoMP4.mp4
  8. National Institute for Health and Care Excellence. Prophylaxis against infective endocarditis: antimicrobial prophylaxis against infective endocarditis in adults and children undergoing interventional procedures [Internet]. [London]: NICE; 2008 [updated 2016 Jul; cited 2022 Oct 17]. (Clinical guideline [CG64]). Available from: https://www.nice.org.uk/guidance/cg64
  9. Heinemann K, Reed S, Moehner S, Minh TD. Risk of uterine perforation with levonorgestrel-releasing and copper intrauterine devices in the European Active Surveillance Study on Intrauterine Devices. Contraception. 2015 Apr 1;91(4):274–9. Available from: https://www.contraceptionjournal.org/article/S0010-7824(15)00008-6/fulltext DOI:10.1016/j.contraception.2015.01.007

Editorial Information

Last reviewed: 01/06/2020

Next review date: 31/12/2023

Author(s): Janice Allan.

Version: 9.1