Dosage, efficacy, side effects and pricing

Warning

Dosing Interval

The recommended dosing interval for intramuscular DMPA (Depo-Provera®) and subcutaneous DMPA (Sayana Press®) is 13 weeks. This is outside the product licence for Depo-Provera®.

DMPA may be administered up to 14 weeks from the last injection without the need for additional contraceptive precautions. This is outside the product licence for Depo-Provera®.

 

 

Efficacy

Perfect use failure rate is 0.2% in the first year of use. Typical use is 6% in the first year of use.

Side Effects

Common side effects

  • Change in menstrual pattern.
  • Delay in return of fertility.
    • Mean time to ovulation is 5.3 months following the preceding injection, i.e., 2 to 3 months following cessation of therapy.
  • Weight gain.

Less common adverse effects

  • Prolonged or very heavy bleeding – history and examination must be taken to exclude gynaecology pathology (e.g., pelvic infection)
  • Anaphylaxis.
  • Galactorrhoea

 

Prices

  • Depo Provera® -  £6.01
  • Sayana Press® - £6.90

As Per BNF May 2022

 

 

Editorial Information

Last reviewed: 01/05/2022

Next review date: 01/05/2024

Author(s): West of Scotland Managed Clinical Network for Sexual Health Clinical Guidelines Group .

Version: 9.1

Approved By: West of Scotland Managed Clinical Network for Sexual Health