Appendix 2: Piperacillin/tazobactam dose banding chart (1 month - 18 years)

Warning

Recommended piperacillin/tazobactam dosing schedule (1 month - 18 years)
Normal renal function assumed.
Dosing schedule should be reviewed/adjusted in reduced renal function - refer to
BNFc and/or liaise with Pharmacist.

Piperacillin/tazobactam can be administered by intravenous infusion or bolus (i.e. injection over 5 minutes, off label), as per Medusa.  

Patient’s weight (kg)

Each dose (mg),
dosed at 4x per day

4.1 – 4.5

375

4.6 – 5.4

450

5.5 – 6.2

525

6.3 – 7.0

600

7.1 – 7.9

675

8.0 – 8.7

750

8.8 - 9.5

825

9.6 – 10.9

900

11.0 – 12.4

1050

12.5 – 14.1

1200

14.2 – 15.8

1350

15.9 – 17.4

1500

17.5 – 19.1

1650

19.2 – 20.8

1800

20.9 – 22.4

1950

22.5 – 24.1

2100

24.2 – 25.8

2250

25.9 – 27.4

2400

27.5 – 29.1

2550

29.2 – 30.8

2700

30.9 – 32.4

2850

32.5 – 34.1

3000

34.2 – 35.8

3150

35.9 – 37.4

3300

37.5 – 39.1

3450

39.2 – 40.8

3600

40.9 – 42.4

3750

42.5 – 44.1

3900

44.2 – 45.8

4050

45.9 – 47.4

4200

47.5 – 49.1

4350

> 49.2

4500

Based on table produced by NHS Greater Glasgow and Clyde.

Editorial Information

Last reviewed: 20/02/2024

Next review date: 20/02/2026

Author(s): Dr Jon van Aartsen (Consultant Microbiologist), Nicola Cameron (Pharmacist).

Version: v1.0

Approved By: AMT (20.02.2024) and ADTC (28.02.2024)

Reviewer name(s): Dr Jed Bamber (Consultant Paediatrician), AMS Team.