Consider hospital admission.
Consider goals of care.
Discuss with senior colleague.
Send blood cultures
Consider C. difficile as a differential diagnosis in all patients presenting with abdominal pain.
Diarrhoea is not always present in severe infection where the white cell count can be raised and abdominal pain and guarding and signs of ileus are present.
Options for effectively treating a severe intra-abdominal infection are limited. Making a diagnosis is a priority to guide effective therapy and future care.
Preferred:
Amoxicillin 1g orally every eight hours
PLUS
Gentamicin intravenous as per NHS Lothian online calculator
PLUS
Metronidazole 400mg orally every 8 hours
Penicillin allergy:
Teicoplanin intravenous (see Appendix 2 for protocol)
PLUS
Gentamicin intravenous as per NHS Lothian online calculator
PLUS
Metronidazole 400mg orally every 8 hours
Alternative/ oral option:
Co-trimoxazole 960mg orally every 12 hours
(see Appendix 1 for dose reduction in renal impairment)
PLUS
Metronidazole 400mg orally every 8 hours
If oral route not available very limited options are available for community management.
If antibiotic therapy deemed appropriate:
Amoxicillin 2g intravenous every 12 hours
PLUS
Gentamicin intravenous as per NHS Lothian online calculator
PLUS
Metronidazole 1g by rectum every 8 hours for 3 days, then 1g by rectum
every 12 hours
Penicillin allergy and no oral option:
Teicoplanin intravenous (see Appendix 2 for protocol)
PLUS
Gentamicin intravenous as per NHS Lothian online calculator
PLUS
Metronidazole 1g by rectum every 8 hours for 3 days, then 1g by rectum
every 12 hours
Gentamicin should not be extended for more than 72 hours in H@H patients without advice from an infection specialist, with consideration of toxicities and monitoring. (Note this differs from advice for patients in acute care settings where up to 5 days may be given).
If the patient is responding and there are no positive culture results, consider oral co-trimoxazole and metronidazole to complete antibiotic course.