Source control through drainage of pus or surgical resection provides optimal treatment; consider referral for surgical assessment.

Organisms:

Community associated diarrhoea – viruses, Campylobacter and C. difficile

Intra-abdominal infections are often polymicrobial with enterobacteriaceae, anaerobes, Streptococci, enterococci.

Investigations:

Stool culture and C.difficile testing if diarrhoea.

Blood cultures if febrile

Mild cholecystitis or mild diverticulitis (H@H)

No antimicrobials recommended (East Region Formulary).

Consider C. difficile as a differential diagnosis in all patients presenting with abdominal pain.  Diarrhoea is not always present in severe infection where the white cell count can be raised and abdominal pain and guarding and signs of ileus are present.

C.difficile infection (H@H)

Take bloods and use East Region Formulary https://www.formulary.nhs.scot/east/infections/gastro-intestinal/clostridioides-difficile/ for appropriate treatment.

If the patient is a care home resident and has CDI then consult with the health protection team in Public Health for advice regarding reducing the risk of transmission to other residents

Severe intra-abdominal sepsis (H@H)

Consider hospital admission.

Consider goals of care.

Discuss with senior colleague.

Send blood cultures

Consider C. difficile as a differential diagnosis in all patients presenting with abdominal pain.

Diarrhoea is not always present in severe infection where the white cell count can be raised and abdominal pain and guarding and signs of ileus are present.

Options for effectively treating a severe intra-abdominal infection are limited. Making a diagnosis is a priority to guide effective therapy and future care.

Preferred:

Amoxicillin 1g orally every eight hours

PLUS

Gentamicin intravenous as per NHS Lothian online calculator

PLUS

Metronidazole 400mg orally every 8 hours

Penicillin allergy:

Teicoplanin intravenous (see Appendix 2 for protocol)

PLUS

Gentamicin intravenous as per NHS Lothian online calculator

PLUS

Metronidazole 400mg orally every 8 hours

Alternative/ oral option:

Co-trimoxazole 960mg orally every 12 hours

(see Appendix 1 for dose reduction in renal impairment)

PLUS

Metronidazole 400mg orally every 8 hours

 

If oral route not available very limited options are available for community management.

If antibiotic therapy deemed appropriate:

Amoxicillin 2g intravenous every 12 hours

PLUS

Gentamicin intravenous as per NHS Lothian online calculator

PLUS

Metronidazole 1g by rectum every 8 hours for 3 days, then 1g by rectum

every 12 hours

 

Penicillin allergy and no oral option:

Teicoplanin intravenous (see Appendix 2 for protocol)

PLUS

Gentamicin intravenous as per NHS Lothian online calculator

PLUS

Metronidazole 1g by rectum every 8 hours for 3 days, then 1g by rectum

every 12 hours

Gentamicin should not be extended for more than 72 hours in H@H patients without advice from an infection specialist, with consideration of toxicities and monitoring.  (Note this differs from advice for patients in acute care settings where up to 5 days may be given).

If the patient is responding and there are no positive culture results, consider oral co-trimoxazole and metronidazole to complete antibiotic course.