First Line

Important: Therapy

Ceftriaxone 2g IV 24 hourly (administered as per local SOP)

or

Linezolid 600mg PO 12 hourly

(risk of serious drug interactions with linezolid – check BNF or discuss with pharmacy)

Notes:

Important: Notes

Mark boundary of cellulitis and review regularly.

Patients with severe cellulitis can deteriorate rapidly. Consider admission, especially if severe pain, rapid spread of cellulitis or haemodynamically unstable.

It is recommended to send swab(s) for culture where there has been poor clinical response to an empirical antibiotic previously or where antibiotic options are limited e.g. allergy, drug interaction. Even if no break in skin a firm swab of most cellulitic area may yield pathogen to guide management.

Treatment duration: 7 days (may be longer depending on severity of systemic infection and clinical response)